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Lingguizhugan Decoction, a Chinese herbal formula, improves insulin resistance in overweight/obese subjects

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 745-759 doi: 10.1007/s11684-021-0880-3

Abstract: Lingguizhugan Decoction (LGZG) has been investigated in basic studies, with satisfactory effects on insulin resistance in non-alcoholic fatty liver disease (NAFLD). This translational approach aimed to explore the effect and underlying mechanism of LGZG in clinical setting. A randomized, double-blinded, placebo-controlled trial was performed. A total of 243 eligible participants with NAFLD were equally allocated to receive LGZG (two groups: standard dose and low dose) or placebo for 12 weeks on the basis of lifestyle modifications. The primary efficacy variable was homeostasis model assessment of insulin resistance (HOMA-IR). Analyses were performed in two populations in accordance with body mass index (BMI; overweight/obese, BMI ≥ 24 kg/m2; lean, BMI < 24 kg/m 2). For overweight/obese participants, low-dose LGZG significantly decreased their HOMA-IR level compared with placebo (−0.19 (1.47) versus 0.08 (1.99),P = 0.038). For lean subjects, neither dose of LGZG showed a superior effect compared with placebo. Methylated DNA immunoprecipitation sequencing and real-time qPCR found that the DNA N6-methyladenine modification levels of protein phosphatase 1 regulatory subunit 3A (PPP1R3A) and autophagy related 3 (ATG3) significantly increased after LGZG intervention in overweight/obese population. Low-dose LGZG effectively improved insulin resistance in overweight/obese subjects with NAFLD. The underlying mechanism may be related to the regulation of DNA N6-methyladenine modification of PPP1R3A and ATG3. Lean subjects may not be a targeted population for LGZG.

Keywords： insulin resistance     non-alcoholic fatty liver disease     Chinese herbal medicine     randomized controlled    

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The Globalization of Traditional Medicines: Perspectives Related to the European Union Regulatory Environment Perspective

Werner Knoess, Jacqueline Wiesner

Engineering 2019, Volume 5, Issue 1,   Pages 22-31 doi: 10.1016/j.eng.2018.11.012

Abstract: medicinal products and traditional herbal medicinal products.The standards defined by the EU herbal monographs of the Committee on Herbal Medicinal Products (HMPCmedicines from traditional Chinese medicine (TCM) to gain access to the EU market.provides specific guidance documents and pilot projects on monographs on the safety and efficacy of Chineseherbal drugs.

Keywords： Traditional medicine     Traditional Chinese medicine     Committee on Herbal Medicinal Products     Herbal medicines    

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Bioactive Components of Chinese Herbal Medicines in the Treatment of Glucose and Lipid Metabolism Disorders Review

Ying Zhang, Jiaming Ju, Lei Jiao, Baofeng Yang

Engineering 2023, Volume 29, Issue 10,   Pages 73-82 doi: 10.1016/j.eng.2023.03.004

Abstract: Traditional Chinese medicine, mainly Chinese herbal medicine (CHM), has a history of more than 2000 years

Keywords： Chinese herbal medicines     Hyperlipidemia     Hyperglycemia     Cardiovascular and cerebrovascular diseases    

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Prospect in Creating New Drugs from Chinese Herbal Medicine

Yu Dequan

Strategic Study of CAE 1999, Volume 1, Issue 2,   Pages 87-90

Abstract: herbal medicine has proved to be one of the most effective ways for the development of new drugs.

The key point of study on the chemical constituents of individual Chinese herbal medicine hasto be shifted to composite Chinese medicine especially for quality control in the future.study of the chemical constituents of composite Chinese medicine.Study on the bioactive principle of Chinese herbal medicine involves an integration of chemical study

Keywords： natural product research     creating new drug     chemical constituent of Chinese herbal medicine     modem spectroscopic    

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Research Progress in the Application of Chinese Herbal Medicines in Aquaculture: A Review

Hongyu Pu, Xiaoyu Lia, Qingbo Du, Hao Cui, Yongping Xua

Engineering 2017, Volume 3, Issue 5,   Pages 731-737 doi: 10.1016/J.ENG.2017.03.017

Abstract: As a result, Chinese herbal medicines are being increasingly used, coining the use of the term &ldquo” Research shows that Chinese herbal medicines have many beneficial effects on fish, includingMany effective ingredients have been discovered in Chinese herbal medicines, which function to promoteThis article reviews the latest research and application progress in Chinese herbal medicines regardingwith the application of Chinese herbal medicines in fish culture.

Keywords： Aquaculture     Chinese herbal medicines     Fish farming     Research progress    

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The Scientific Foundation of Chinese Herbal Medicine against COVID-19 Perspective

Elaine Lai-Han Leung, Hu-Dan Pan, Yu-Feng Huang, Xing-Xing Fan, Wan-Ying Wang, Fang He, Jun Cai, Hua Zhou, Liang Liu

Engineering 2020, Volume 6, Issue 10,   Pages 1099-1107 doi: 10.1016/j.eng.2020.08.009

Abstract: Traditional Chinese medicine could be used as an alternative treatment option or in combination withHere, we summarize the potential uses and therapeutic mechanisms of Chinese herbal formulas (CHFs) from

Keywords： Coronavirus disease 2019     Severe acute respiratory syndrome coronavirus     Chinese herbal medicine     Antiviral    

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Chinese herbal medicine reduces mortality in patients with severe and critical coronavirus disease 2019

Guohua Chen, Wen Su, Jiayao Yang, Dan Luo, Ping Xia, Wen Jia, Xiuyang Li, Chuan Wang, Suping Lang, Qingbin Meng, Ying Zhang, Yuhe Ke, An Fan, Shuo Yang, Yujiao Zheng, Xuepeng Fan, Jie Qiao, Fengmei Lian, Li Wei, Xiaolin Tong

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 752-759 doi: 10.1007/s11684-020-0813-6

Abstract: This study aimed to evaluate the efficacy of Chinese herbal medicine (CHM) in patients with severe/critical

Keywords： COVID-19     CHM     mortality     a retrospective cohort study    

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Symptom network topological features predict the effectiveness of herbal treatment for pediatric cough

Mengxue Huang, Jingjing Wang, Runshun Zhang, Zhuying Ni, Xiaoying Liu, Wenwen Liu, Weilian Kong, Yao Chen, Tiantian Huang, Guihua Li, Dan Wei, Jianzhong Liu, Xuezhong Zhou

Frontiers of Medicine 2020, Volume 14, Issue 3,   Pages 357-367 doi: 10.1007/s11684-019-0699-3

Abstract: total of 384 cases were derived from the electronic medical records of a highly experienced traditional Chinese

Keywords： pediatric cough     complex network     symptoms     traditional Chinese medicine     electronic medical records    

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Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-known liver-restorative herb

Jiabo Wang,Zhijie Ma,Ming Niu,Yun Zhu,Qingsheng Liang,Yanling Zhao,Jingyuan Song,Zhaofang Bai,Yaming Zhang,Ping Zhang,Na Li,Yakun Meng,Qi Li,Lushan Qin,Guangju Teng,Junling Cao,Baosen Li,Shilin Chen,Yonggang Li,Zhengsheng Zou,Honghao Zhou,Xiaohe Xiao

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 457-467 doi: 10.1007/s11684-015-0417-8

Abstract:

Herbal medicines have recently been recognized as the second most common cause of drug-induced liverscreening methods for Heshouwu DILI diagnosis addresses safety concerns regarding stilbene-containing herbal

Keywords： drug-induced liver injury     pharmacognosy     metabolomics     stilbene     Polygonum multiflorum     Chinese herbal    

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Practice and principle of traditional Chinese medicine for the prevention and treatment of COVID-19

Frontiers of Medicine doi: 10.1007/s11684-023-1040-8

Abstract: Traditional Chinese medicine (TCM) has played an important role in the prevention and treatment of coronavirusThe integration of Chinese and Western medicine is an important feature of Chinese COVID-19 prevention

Keywords： traditional Chinese medicine     COVID-19     SARS-CoV-2     clinical evidence-based study     mechanism     integratedtraditional Chinese and Western medicine    

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Practices, challenges, and opportunities: HIV/AIDS treatment with traditional Chinese medicine in China

Jian Wang, Wen Zou

Frontiers of Medicine 2011, Volume 5, Issue 2,   Pages 123-126 doi: 10.1007/s11684-011-0124-z

Abstract: Traditional Chinese medicine (TCM) has become widely used in the treatment of acquired immune deficiency

Keywords： HIV/AIDS     traditional Chinese medicine    

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Systematic review for geo-authentic Lonicerae Japonicae Flos

Xingyue Yang, Yali Liu, Aijuan Hou, Yang Yang, Xin Tian, Liyun He

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 203-213 doi: 10.1007/s11684-017-0504-0

Abstract:

In traditional Chinese medicine, Lonicerae Japonicae Flos is commonly used as anti-inflammatory, antiviral, and antipyretic herbal medicine, and geo-authentic herbs are believed to present the highest qualityTo discuss the current situation and trend of geo-authentic Lonicerae Japonicae Flos, we searched ChineseBiomedicine Literature Database, Chinese Journal Full-text Database, Chinese Scientific Journal Full-text

Keywords： Lonicerae Japonicae Flos     geo-authentic     herbal quality     chemical fingerprint     component analysis    

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Individualized medicine, health medicine, and constitutional theory in Chinese medicine

Qi Wang

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 1-7 doi: 10.1007/s11684-012-0173-y

Abstract: Chinese and Western medical systems are dissimilar in terms of value orientations, thinking style, andThe Chinese constitutional theory developed in the 1970s expresses the principle behind Chinese healthThe Chinese constitutional theory divides the constitution of the Chinese population into nine categoriesIt promotes the study of the relationship of each constitution to diseases and Chinese medicine preparationdisease-differentiation, and syndrome-differentiation can be established for the development of individualized Chinese

Keywords： individualized medicine     health medicine     constitutional theory in Chinese medicine    

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Barriers and countermeasures in developing traditional Chinese medicine in Europe

Yunfang Liu,Zhiping Yang,Jing Cheng,Daiming Fan

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 360-376 doi: 10.1007/s11684-016-0455-x

Abstract:

Traditional Chinese medicine (TCM) is one of the unique cultural treasures of Chinese; it representsData in this paper were from World Health Organization, Chinese Bureau of Statistics, China National

Keywords： traditional Chinese medicine     Europe     development    

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Named entity recognition for Chinese construction documents based on conditional random field

Frontiers of Engineering Management 2023, Volume 10, Issue 2,   Pages 237-249 doi: 10.1007/s42524-021-0179-8

Abstract: This study presents a NER method for Chinese construction documents based on conditional random field

Keywords： NER     NLP     Chinese language     construction document    

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Title Author Date Type Operation

Lingguizhugan Decoction, a Chinese herbal formula, improves insulin resistance in overweight/obese subjects

Journal Article

The Globalization of Traditional Medicines: Perspectives Related to the European Union Regulatory Environment

Werner Knoess, Jacqueline Wiesner

Journal Article

Bioactive Components of Chinese Herbal Medicines in the Treatment of Glucose and Lipid Metabolism Disorders

Ying Zhang, Jiaming Ju, Lei Jiao, Baofeng Yang

Journal Article

Prospect in Creating New Drugs from Chinese Herbal Medicine

Yu Dequan

Journal Article

Research Progress in the Application of Chinese Herbal Medicines in Aquaculture: A Review

Hongyu Pu, Xiaoyu Lia, Qingbo Du, Hao Cui, Yongping Xua

Journal Article

The Scientific Foundation of Chinese Herbal Medicine against COVID-19

Elaine Lai-Han Leung, Hu-Dan Pan, Yu-Feng Huang, Xing-Xing Fan, Wan-Ying Wang, Fang He, Jun Cai, Hua Zhou, Liang Liu

Journal Article

Chinese herbal medicine reduces mortality in patients with severe and critical coronavirus disease 2019

Guohua Chen, Wen Su, Jiayao Yang, Dan Luo, Ping Xia, Wen Jia, Xiuyang Li, Chuan Wang, Suping Lang, Qingbin Meng, Ying Zhang, Yuhe Ke, An Fan, Shuo Yang, Yujiao Zheng, Xuepeng Fan, Jie Qiao, Fengmei Lian, Li Wei, Xiaolin Tong

Journal Article

Symptom network topological features predict the effectiveness of herbal treatment for pediatric cough

Mengxue Huang, Jingjing Wang, Runshun Zhang, Zhuying Ni, Xiaoying Liu, Wenwen Liu, Weilian Kong, Yao Chen, Tiantian Huang, Guihua Li, Dan Wei, Jianzhong Liu, Xuezhong Zhou

Journal Article

Evidence chain-based causality identification in herb-induced liver injury: exemplification of a well-known liver-restorative herb

Jiabo Wang,Zhijie Ma,Ming Niu,Yun Zhu,Qingsheng Liang,Yanling Zhao,Jingyuan Song,Zhaofang Bai,Yaming Zhang,Ping Zhang,Na Li,Yakun Meng,Qi Li,Lushan Qin,Guangju Teng,Junling Cao,Baosen Li,Shilin Chen,Yonggang Li,Zhengsheng Zou,Honghao Zhou,Xiaohe Xiao

Journal Article

Practice and principle of traditional Chinese medicine for the prevention and treatment of COVID-19

Journal Article

Practices, challenges, and opportunities: HIV/AIDS treatment with traditional Chinese medicine in China

Jian Wang, Wen Zou

Journal Article

Systematic review for geo-authentic Lonicerae Japonicae Flos

Xingyue Yang, Yali Liu, Aijuan Hou, Yang Yang, Xin Tian, Liyun He

Journal Article

Individualized medicine, health medicine, and constitutional theory in Chinese medicine

Qi Wang

Journal Article

Barriers and countermeasures in developing traditional Chinese medicine in Europe

Yunfang Liu,Zhiping Yang,Jing Cheng,Daiming Fan

Journal Article

Named entity recognition for Chinese construction documents based on conditional random field

Journal Article